The Role of Genetic Mutations in Genes WNK1, WNK4, CUL3, KLHL3 in Gordon’s Syndrome

Gordon's syndrome, also known as Pseudohypoaldosteronism, that is type II (PHAII), is a genetic disorder that affects the amount of sodium and potassium in the body. People with Gordon syndrome have high blood pressure (hypertension) and high levels of potassium in the blood (hyperkalemia), despite having normal kidney function. The Gordon syndrome is based on the mutation of the WNK1,WNK4, CUL3, KLHL3 genes.

Keywords: Gordon's syndrome, genetic mutations, WNK1,WNK4,CUL3,KLHL3 genes.